Synthesis of glycosaminoglycans by islets of Langerhans |
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| Authors: | D T Watkins S J Cooperstein |
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| Institution: | Department of Anatomy, University of Connecticut School of Medicine, Farmington 06032. |
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| Abstract: | Incorporation of (35S)-sulfate into glycosaminoglycans (GAG) of toadfish islets of Langerhans in vitro was examined. (35S)-sulfated GAG were synthesized by a component of the microsomal fraction, and subsequently transferred to the secretion granules, mitochondria and nuclei. The predominant type of GAG synthesized was heparan sulfate, but chondroitin 4- and 6-sulfate and dermatan sulfate were also found. |
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