| 黄酮和甾体类化合物的抗真菌活性 |
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| 引用本文： | 周立刚 张颖君. 黄酮和甾体类化合物的抗真菌活性[J]. 天然产物研究与开发, 1997, 9(3): 24-29 |
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| 作者姓名： | 周立刚 张颖君 |
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| 作者单位： | 华中理工大学药物研究所，中国科学院昆明植物研究所，中国科学院昆明植物研究所，中国科学院昆明植物研究所，中国科学院昆明植物研究所，华中理工大学药物研究所，中国科学院昆明植物研究所 武汉 430074，昆明 650204，昆明 650204 贵阳医学院1996年实习生，贵阳市武当区防疫站，昆明 650204，昆明 650204，武汉 430074，昆明 650204 |
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| 基金项目： | 云南省应用基础研究基金(95B087Q) |
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| 摘 要： | 用琼脂扩散法对从药用植物中分离到的12个黄酮和5个甾体化合物进行了抗真菌活性实验,其中黄芩甙元(baicalein)、funkioside C和胡萝卜甙(daucosterol)对尖孢镰刀菌(Fusarium oxysporum)和白色念珠菌(Candida albicans)的生长均有抑制作用,对尖孢镰刀菌的最低抑菌浓度(MIC)分别为0.112、0.217和0.108g/L,对白色念珠菌的MIC分别为0.264、0.310和0.078g/L。对其构效关系进行了初步讨论。
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| 关 键 词： | 黄酮 甾体 尖孢镰刀菌 白色念珠菌 抗真菌活性 |
ANTIFUNGAL ACTIVITIES IN VITRO OF FLAVONOIDS AND STEROIDS FROM MEDICINAL PLANTS |
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| Zhou Ligang,Zhang Yingyun,Cai Yan,Liu yuqing,Wang Jinliang,Wang Junjian,Yang Chongren. ANTIFUNGAL ACTIVITIES IN VITRO OF FLAVONOIDS AND STEROIDS FROM MEDICINAL PLANTS[J]. Natural Product Research and Development, 1997, 9(3): 24-29 |
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| Authors: | Zhou Ligang Zhang Yingyun Cai Yan Liu yuqing Wang Jinliang Wang Junjian Yang Chongren |
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| Abstract: | The antifungal activities of. 12 flavonoids and 5 steroids were screened by the method of agar diffusion test. Compounds baicalein(1) ,funkioside C(14)and daucosterol(17)showed antifungal activities of inhibiting growth of both Fusarium oxysporum and Candida albicans. The values of minimal inhibitory concentration (MIC) of compounds 1,14 and 17 on growth of F. oxysporum were measured as 0. 112g/L,0. 217g/L and 0. 109g/L respectively,and MIC values of Compounds 1,14 and 17 on growth of C. albicans were measured as 0. 264g/L, 0. 310g/L and 0. 078g/L respectively. The relationships between the structures and their antifungal activities were discussed. |
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| Keywords: | flavonoids steroids Fusarium oxysporum Candida albicans antifungal activities |
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