| 重组葡激酶（r—Sak）在家兔体内的药代动力学研究 |
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| 引用本文： | 杨伟,李伯刚,周正质,赵德英,邱芬,张罗红.重组葡激酶（r—Sak）在家兔体内的药代动力学研究[J].天然产物研究与开发,1997,9(2):71-75. |
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| 作者姓名： | 杨伟 李伯刚 周正质 赵德英 邱芬 张罗红 |
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| 作者单位： | 中科院成都地奥制药公司，中科院成都地奥制药公司，中科院成都地奥制药公司，中科院成都地奥制药公司，中科院成都地奥制药公司，四川省药检所 成都 610036，成都 610036，成都 610036，成都 610036，成都 610036，成都 610036 |
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| 摘 要： | 家兔静脉注射重组葡激酶(r-Sak)后,经用二室模型(权重系数1/C)计算。结果表明,该药分布相较短,t1/2α约为1.11±0.72 min,消除也快,t1/2β约为8.64±0.21min,但在胆汁及尿液中未测出r-Sak的生物活性。
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| 关 键 词： | 重组葡激酶(r-Sak) 药代动力学参数 家兔 |
PHARMACOKINETIC STUDIES OF RECOMBINANT STAPHYLOKINASE(R-SAK)IN RABBITS |
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| Yang Wei,Li Bogang,Zhou Zengzhi,Zhao Deying,Qiu Fen.PHARMACOKINETIC STUDIES OF RECOMBINANT STAPHYLOKINASE(R-SAK)IN RABBITS[J].Natural Product Research and Development,1997,9(2):71-75. |
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| Authors: | Yang Wei Li Bogang Zhou Zengzhi Zhao Deying Qiu Fen |
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| Abstract: | The pharmacokinetic parameters of Human recombinant staphylokinase were studied with analyzing fibrinolytic activity method. The plasma concentration-time curve of r-Sak after iv 1. 35, 0. 45 mg/kg into rabbits was found to fit a two-compartment model,tl/2@ was 1. 11@0. 72 min and tl/2@ was 8. 64@0. 21 min. It was shown that r-Sak eliminated from plasma was very fast. r-Sak was not found in bile and urine. |
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| Keywords: | Recombinant staphylokinase (r-Sak) Pharmacokinetic parameters Rabbit |
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