Comparing the performance of one-column process and four-zone simulated moving bed by computer simulation |
| |
Authors: | Young?Sik?Kim Chong?Ho?Lee Phillip?C?Wankat Email author" target="_blank">Yoon?Mo?KooEmail author |
| |
Institution: | (1) Department of Biological Engineering, ERC for Advanced Bioseparation Technology, Inha University, 402-751 Incheon, Korea;(2) School of Chemical Engineering, Purdue University, 47907 West Lafayette, IN, USA |
| |
Abstract: | A new one-column chromatography process, analogous to a four-zone simulated moving bed (SMB), was presented. The basic principle
of the process was identical to that of a four-zone SMB. The process consisted of one chromatographic column and four tanks,
instead of the four columns in the four-zone SMB (1-1-1-1), and has been used for the separation of two amino acids, phenylalanine
and tryptophan, using an ion exchange resin. The operating parameters for the one-column process and four-zone SMB were obtained
from equilibrium theory. Computer simulations were used to compare the performances of the new one column process to that
of the general four-zone SMB, using Aspen Chromatography™ v 11.1. The differences between the one-column and SMB processes in terms of the purities and yields of phenylalanine and
tryptophan were less than 4 and about 6%, respectively. The lower purities of the one-column process were due to the loss
of the developed concentration profiles in the column when the liquid was stored in tanks. The one-column process gave great
flexibility, and would be useful for reconstructing an existing conventional chromatography process to one of a SMB. |
| |
Keywords: | simulated moving bed one-column process computer simulation amino acid |
本文献已被 SpringerLink 等数据库收录! |
|