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CARMA: A platform for analyzing microarray datasets that incorporate replicate measures |
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| Authors: | Kevin A Greer Matthew R McReynolds Heddwen L Brooks James B Hoying |
| Institution: | (1) Biomedical Engineering Program, Genomics Research Laboratory, University of Arizona, Tucson, Arizona 85724, USA;(2) Department of Physiology, University of Arizona, College of Medicine, 1501 N Campbell Ave, Tucson, Arizona 85724, USA |
| Abstract: | BackgroundThe incorporation of statistical models that account for experimental variability provides a necessary framework for the interpretation of microarray data. A robust experimental design coupled with an analysis of variance (ANOVA) incorporating a model that accounts for known sources of experimental variability can significantly improve the determination of differences in gene expression and estimations of their significance. |
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