Design and synthesis of trans 2-(furan-2-yl)vinyl heteroaromatic iodides with antitumour activity |
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| Authors: | Fortuna Cosimo Gianluca Barresi Vincenza Berellini Giuliano Musumarra Giuseppe |
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| Affiliation: | Dipartimento di Scienze Chimiche, Università di Catania, Viale A. Doria, 6, 95125 Catania, Italy. cg.fortuna@unict.it |
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| Abstract: | A new molecular modelling approach based on physico-chemical and pharmacokinetic properties, called Volsurf plus, was used to design new heterocyclic compounds with antiproliferative activity. The synthesis and in vitro antitumour tests on a breast carcinoma cell line (MCF7) confirmed VOLSURF predicted activity values. |
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