Membrane abnormalities of Huntington's chorea fibroblasts in culture.

Huntington's Chorea is an autosomal dominant disease of the nervous system. Proliferating fibroblasts of one such case express metabolic and morphological abnormalities in addition to delayed adhesion to plastic substratum when compared to age, sex and passage number matched human fibroblasts when grown in a minimal essential medium supplemented with glycine or serine and the macromolecular fraction of fetal calf serum. The abnormalities expressed by Huntington's Chorea fibroblasts are fully corrected when the fibroblasts are grown in whole non-filtered fetal calf serum or when 10^?3 M glucosamine is added to the culture medium.