非小细胞肺癌中E-钙粘素和CD44v6的表达及其意义

为了探讨E-钙粘素(E-cadherin,E-cad)和白细胞分化抗原变异型6(CD44v6)在非小细胞肺癌(NSCLC)中的表达及临床意义,采用免疫组织化学(SP法)对65例NSCLC和20例癌旁组织中E-cad和CD44v6的表达进行研究。结果显示E-cad在肺癌组织中的阳性表达率(32.31%)显著低于癌旁组织(75.00%)(P<0.01),且与NSCLC的TNM分期、淋巴结转移呈负相关(P<0.05),与分化程度呈正相关(P<0.01),而与组织分型无关(P>0.05);CD44v6的阳性表达率与组织分型和分化程度无关(P>0.05),而与TNM分期和淋巴结转移呈正相关(P<0.05,<0.01)。两者在NSCLC中的表达显著相关(P<0.05)。因此检测E-cad和CD44v6的共同表达将是指导临床治疗及估计预后的有意义指标,可应用于临床预后的综合评价。

Significance and expression of E-cadherin and CD44v6 in patients with non-small cell lung cancer

To investigate the expression of E-cadherin and CD44v6 in NSCLC and to find their clinical significance. High sensitive S-P immunohistochemical method was used to detect the expression of E-cadherin and CD44v6 in 65 cases of NSCLC and 20 samples from of adjacent nonneoplastic tissues. The positive rates of E-cadherin expression (32.31%)in NSCLC were apparently lower than those in adjacent normal tissues(75.00%)(P<0.01),which were negatively correlated to TNM stages and lymph node metastasis(P<0.05) respectively and were positively correlated to differentiations( P<0.01).However the positive rates of E-cadherin expression have not related with the histological types of NSCLC(P>0.05).There was no significant correlation between the positive rates of CD44v6 expression and the histological types of tumor and differentiations(P>0.05).It was positively correlated to TNM stages and lymph node metastasis(P<0.05,(<0.01)).The association between the expression of E-cadherin and CD44v6 is significant in NSCLC(P<0.05). The concordant rate of E-cadherin and CD44v6 expression was relatively high in NSCLC. They can be used as markers of treatment and prognosis of NSCLC in clinical practice.