The molecular nature of benzimidazole resistance in helminths

The economic importance of benzimidazole (BZ) resistance has resulted in the isolation of resistant populations of helminths and their study (see pp 127-129 this issue). Recent research indicates that BZs act by binding to free beta-tubulin in the cell and inhibiting the formation of microtubules. The effects of BZs on other processes in the cell, such as transport and anaerobic metabolism, probably result from the inhibition of one or more of the functions of tubulin (see pp 112-115, this issue). In this article, Marleen Roos examines the evidence for changes in the beta-tubulin structure and the rate of its synthesis in BZ-resistant parasitic nematodes.