The production of 99mTc-labeled conjugated antibodies using a cyclam-based bifunctional chelating agent |
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| Institution: | 1. School of Biological Sciences, Illinois State University, Normal, IL 61790, USA;2. Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA |
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| Abstract: | A bifunctional chelating agent (BFCA) based on a macrocyclic amine, cyclam, was used to form specifically 99mTc labeled rabbit-anti-HSA-antibodies. This study demonstrates the feasibility of forming a highly stable cyclam-based 99mTc-BFCA with its subsequent conjugation to antibodies. |
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