Enzyme mediated resolution of alcohols |
| |
| Authors: | Marie Zarevúcka Martin Rejzek Milan Pavlík Zdeněk Wimmer Jan Zima Marie-Dominique Legoy |
| |
| Institution: | (1) Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám stí 2, 6 Prague, Czech Republic;(2) Laboratory of Enzymatic Technology, University of Technology, P.O.B. 649, F-60206 Compiegne, France |
| |
| Abstract: | Summary The racemic cis and trans isomers 1a and 1b of 2-(4-methoxybenzyl)-1-cyclohexanol were subjects of an enzyme mediated resolution via esterification in organic solvents, in which the chiral esters 2a and 2b of the corresponding alcohols 4a and 4b, and the chiral alcohols 3a and 3b were obtained. The chemical yield and enantioselectivity of this enzymatic reaction have been found to depend mainly on (a) the structure of the substrate (cis or trans), (b) temperature, (c) the nature of the enzyme selected, and (d) the nature of the solvent. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
