Chromosomal assignment in mouse of matrix Gla protein and bone Gla protein genes. |
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Authors: | T L Johnson A Y Sakaguchi P A Lalley R J Leach |
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Affiliation: | Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284. |
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Abstract: | Matrix Gla protein (MGLAP) and bone Gla protein (BGLAP) are calcium-binding, vitamin K-dependent proteins produced by cells of the osteoblastic lineage. Sequence homology suggests that the genes for these proteins evolved from a common ancestor. Somatic whole cell hybrids and karyotypically simple microcell hybrids were used to map Mglap to mouse Chromosome 6 and Bglap to mouse Chromosome 3. Human MGLAP has previously been mapped to chromosome 12p, a region with homology to mouse Chromosome 6, and human BGLAP has been mapped to chromosome 1q, a region with homology to mouse Chromosome 3. It appears that BGLAP is the third calcium-binding protein that maps to human chromosome 1q and mouse Chromosome 3. |
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