Ama "zinc" link between TrkB transactivation and synaptic plasticity |
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| Authors: | Nagappan Guhan Woo Newton H Lu Bai |
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| Affiliation: | Section on Neural Development and Plasticity, National Institute of Child Health and Human Development, National Institutes of Health, 35 Lincoln Drive, Bethesda, MD 20892-3714, USA. |
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| Abstract: | While Trk receptors can be activated in a neurotrophin-independent manner through "transactivation" by GPCR ligands, its physiological significance in the brain remains unknown. Huang et al. have now identified a novel mechanism of TrkB transactivation. They show that zinc ions can transactivate TrkB independent of neurotrophins and that such a transactivation is important for mossy fiber long-term potentiation (LTP). |
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