Methyl-substituted 4-nitropyridine N-oxides as ligands: structural, spectroscopic, magnetic and cytotoxic characteristics of copper(II) complexes |
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Authors: | Puszko Aniela Wasylina Lucyna Pełczynska Marzena Staszak Zbigniew Adach Anna Cieślak-Golonka Maria Kubiak Maria |
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Affiliation: | Department of Bioorganic Chemistry, Faculty of Industry and Economics, Academy of Economics, 53-345 Wroc?aw, Poland. apuszko@credit.ae.wroc.pl |
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Abstract: | Seven new mono- and dinuclear Cu(II) complexes containing various methyl substituted 4-nitropyridine N-oxides as ligands were isolated and characterized physicochemically and biologically. The characterization included elemental analysis, magnetic and spectroscopic methods (diffuse reflectance and UV-visible absorption, IR, FIR). A single crystal X-ray diffraction analysis was performed for the complex with 2,5-dimethyl-4-nitropyridine N-oxide. Trans- and cis-square planar configuration around Cu ion was established for mono- and dinuclear species, respectively. In methanolic solutions the dinuclear species decompose into mononuclear ones with increasing 4 → 6 coordination number with attachment of two solvent molecules.The IR spectra showed that the strength of the Cu-ligand bond gauged by the degree of N-O elongation changed irregularly with position and number of methyl groups. Cytotoxic studies on the MCF-7 human breast cancer line revealed a structure-activity relationship: double blocking of the NO2 group with two CH3 groups rendered the complex completely inactive. |
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Keywords: | Copper complexes Methyl derivatives of 4-nitropyridine N-oxide Spectroscopic and structural methods Cytotoxicity |
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