IS1675, a novel lactococcal insertion element, forms a transposon-like structure including the lacticin 481 lantibiotic operon |
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Authors: | Dufour A Rincé A Uguen P Le Pennec J P |
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Institution: | Laboratoire de Biologie et Chimie Moléculaires, EA 2594, Université de Bretagne Sud, Vannes, France. alain.dufour@univ-ubs.fr |
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Abstract: | Two copies of IS1675, a novel lactococcal insertion element from the IS4 family, are present on a 70-kb plasmid, where they frame the lantibiotic lacticin 481 operon. The whole structure could be a composite transposon designated Tn5721. This study shows that the lacticin 481 operon does not include any regulatory gene and provides a new example of a transposon-associated bacteriocin determinant. We identified five other IS1675 copies not associated with the lacticin 481 operon. The conservation of IS1675 flanking sequences suggested a 24-bp target site. |
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