An ultrahigh-sulphur keratin gene of the human hair cuticle is located at 11q13 and cross-hybridizes with sequences at 11p15 |
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| Authors: | Philip J. MacKinnon Barry C. Powell George E. Rogers Elizabeth G. Baker Ruth N. MacKinnon Valentine J. Hyland David F. Callen Grant R. Sutherland |
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| Affiliation: | (1) Department of Biochemistry, University of Adelaide, 5000 Adelaide, SA, Australia;(2) Department of Cytogenetics and Molecular Genetics, Adelaide Children's Hospital, 5006 North Adelaide, SA, Australia;(3) Present address: Department of Biochemistry, University of Oxford, South Parks Road, OX1 3QU Oxford, United Kingdon;(4) Present address: Kolling Institute of Medical Research, Royal North Shore Hospital, 2065 St. Leonards, NSW, Australia |
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| Abstract: | A human hair cuticle ultrahigh-sulphur keratin (UHSK) gene (KRN1) has been mapped by Southern analysis of a somatic cell hybrid panel and by in situ hybridization. A probe containing the coding region of this gene mapped to 11pter->11q21 using the hybrid cell panel and on in situ hybridization mapped to two regions on chromosome 11: the distal part of 11p15, most likely 11p15.5, and the distal part of 11q13, most likely 11q13.5. A probe from the 3 non-coding region of KRN1 mapped to 11q13.5 indicating that this was the map location of the cloned gene. The sequence of 11p15.5 is termed KRN1-like (KRN1L). The results reveal that the cuticle UHSK gene family is clustered in the human genome.Present address: The Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3, 9DU, United Kingdom. |
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