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PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification
Authors:Idan Cohen  Dejian Zhao  Carmit Bar  Victor J Valdes  Katherine L Dauber-Decker  Minh Binh Nguyen  Manabu Nakayama  Michael Rendl  Wendy A Bickmore  Haruhiko Koseki  Deyou Zheng  Elena Ezhkova
Institution:1. Black Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA;2. Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA;3. Department of Technology Development, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu, Chiba 292-0818, Japan;4. Department of Dermatology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA;5. MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK;6. Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (IMS) and CREST, Japan Science and Technology Agency, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan;7. Departments of Neurology and Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Abstract:
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  • Keywords:polycomb complex  PRC1  skin  epidermis  hair follicle  stem cells  Merkel cell  epigenetics
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