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Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging
Authors:Maria M. Mihaylova  Chia-Wei Cheng  Amanda Q. Cao  Surya Tripathi  Miyeko D. Mana  Khristian E. Bauer-Rowe  Monther Abu-Remaileh  Laura Clavain  Aysegul Erdemir  Caroline A. Lewis  Elizaveta Freinkman  Audrey S. Dickey  Albert R. La Spada  Yanmei Huang  George W. Bell  Vikram Deshpande  Peter Carmeliet  Pekka Katajisto  Ömer H. Yilmaz
Affiliation:1. Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA;2. The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA;3. Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA;4. Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA;5. Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA;6. Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, 3000 Leuven, Belgium;7. Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, 3000 Leuven, Belgium;8. Institute of Biotechnology, HiLIFE, University of Helsinki, P.O. Box 56, Helsinki, Finland;9. Department of Biosciences and Nutrition, Karolinska Institutet, 14183 Stockholm, Sweden;10. Faculty of Arts & Sciences, Department of Molecular Biology and Genetics, Yildiz Technical University, 34210 Istanbul, Turkey;11. Howard Hughes Medical Institute, Chevy Chase, MD, USA
Abstract:
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  • Keywords:stem cells  intestinal stem cells  fasting  aging  metabolism  intestine  fatty acid oxidation  mitochondrial metabolism
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