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Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging
Authors:Maria M Mihaylova  Chia-Wei Cheng  Amanda Q Cao  Surya Tripathi  Miyeko D Mana  Khristian E Bauer-Rowe  Monther Abu-Remaileh  Laura Clavain  Aysegul Erdemir  Caroline A Lewis  Elizaveta Freinkman  Audrey S Dickey  Albert R La Spada  Yanmei Huang  George W Bell  Vikram Deshpande  Peter Carmeliet  Pekka Katajisto  Ömer H Yilmaz
Institution:1. Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA;2. The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA;3. Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA;4. Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA;5. Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA;6. Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, 3000 Leuven, Belgium;7. Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, 3000 Leuven, Belgium;8. Institute of Biotechnology, HiLIFE, University of Helsinki, P.O. Box 56, Helsinki, Finland;9. Department of Biosciences and Nutrition, Karolinska Institutet, 14183 Stockholm, Sweden;10. Faculty of Arts & Sciences, Department of Molecular Biology and Genetics, Yildiz Technical University, 34210 Istanbul, Turkey;11. Howard Hughes Medical Institute, Chevy Chase, MD, USA
Abstract:
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  • Keywords:stem cells  intestinal stem cells  fasting  aging  metabolism  intestine  fatty acid oxidation  mitochondrial metabolism
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