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Metabolic dependence of the fluidity of intact erythrocyte membrane |
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| Authors: | T Kamada S Setoyama Y Chuman S Otsuji |
| Affiliation: | 1. Department of Clinical Laboratory, Kagoshima University Hospital, Faculty of Medicine, Kagoshima University, 1208-1 Usuki-Cho, Kagoshima, 890, Japan;2. Overall Health Control Center, Welfare Federation of Agriculture Cooperatives, 1-13-1 Yojiro, Kagoshima, 890, Japan |
| Abstract: | An S1-nuclease sensitive site exists within supercoiled plasmids containing the 5'-flanking sequences of the human beta-globin gene. This site is located approximately 540 base pairs upstream from the start of the gene within a region of 52 alternating purine-pyrimidine residues which has the potential to adopt either cruciform structures or Z-form DNA. This site is protected from specific cleavage by S1-nuclease by the high-mobility-group chromosomal proteins HMG1 and 2, which may be specifically acting to protect short sequences of single-stranded DNA. |
| Keywords: | PC phosphatidylcholine TBS Tris buffered saline PBS phosphate buffered saline DAG 1,2-diacylglycerol ESR electron spin resonance |
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