Analysis of the possible involvement of the glutamate transporter gene EAAT2 and the glutamate receptor genes GRIA1 and GRIA2 in the pathogenesis of motor neuron disease in the Russian population |
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| Authors: | A L Zherebtsova M I Shadrina E V Semenova G N Levitsky A V Alekhin P A Slominsky V I Skvortsova S A Limborska |
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| Institution: | (1) Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia;(2) Russian State Medical University, Moscow, 129327, Russia |
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| Abstract: | Polymorphisms of the genes of the glutamatergic system EAAT2, GRIA1, and GRIA2 have been analyzed in patients with sporadic motor neuron disease (MND) from Russia. The disease is not associated with polymorphic alleles of the genes studied, which indicates that EAAT2, GRIA1, and GRIA2 play an insignificant role in the pathogenesis of sporadic MND. |
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