Molecular structure of canine LINE-1 elements in canine transmissible venereal tumor |
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Authors: | Choi Y Ishiguro N Shinagawa M Kim C J Okamoto Y Minami S Ogihara K |
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Affiliation: | Department of Veterinary Public Health, Obihiro University of Agriculture and Veterinary Medicine, Japan. |
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Abstract: | We determined the 4251-bp sequence of open reading frame 2 (ORF2) of canine LINE-1 retroposon that encodes 1275 amino acids. The truncated LINE-1 inserts associated with transmissible venereal tumor (TVT) of dogs contained the 1378-bp LINE-1 insert (TVT-LINE) flanked by 10-bp direct repeats upstream to c-myc gene. The TVT-LINE elements were composed of 416 bp inverse sequences homologous to the complementary strand of the LINE-1, a 5-bp deletion and 962-bp sequences homologous to the 3' region of the LINE-1. |
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Keywords: | canine DNA LINE-1 PCR TVT |
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