Linkage and Association Studies of the Susceptibility Genes for Type 2 Diabetes |
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Authors: | Qing-Yang HUANG Meng-Rong CHENG |
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Institution: | a College of Life Science, Central China Normal University, Wuhan 430079, China b Department of Medicine, the University of Hong Kong, Hong Kong, China |
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Abstract: | Type 2 diabetes mellitus (T2DM) is a complex disease characterized by hyperglycemia, insulin resistance, and impaired insulin secretion. T2DM is under strong genetic control. Identification and characterization of genes involved in determining T2DM will contribute to a greater understanding of the pathogenesis of T2DM, and ultimately might lead to the development of better diagnosis, prevention and treatment strategies. Efforts to identify T2DM susceptibility genes have focused on candidate gene approach (association studies) and genome-wide scans (linkage analyses). In this article, we review the current status for mapping and identification of genes for T2DM, with a focus on some promising regions (or genes) and future prospects. |
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Keywords: | type 2 diabetes genetics association studies candidate genes genome-wide scans |
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