Identifying concerted evolution and gene conversion in mammalian gene pairs lasting over 100 million years |
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Authors: | Andrew R Carson Stephen W Scherer |
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Institution: | (1) The Centre for Applied Genomics, Program in Genetics & Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada;(2) Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada |
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Abstract: | Background Concerted evolution occurs in multigene families and is characterized by stretches of homogeneity and higher sequence similarity
between paralogues than between orthologues. Here we identify human gene pairs that have undergone concerted evolution, caused
by ongoing gene conversion, since at least the human-mouse divergence. Our strategy involved the identification of duplicated
genes with greater similarity within a species than between species. These genes were required to be present in multiple mammalian
genomes, suggesting duplication early in mammalian divergence. To eliminate genes that have been conserved due to strong purifying
selection, our analysis also required at least one intron to have retained high sequence similarity between paralogues. |
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