Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis |
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Authors: | Qi Li Ling Shen Tianchi Xin Wenjuan Xiang Wenlian Chen Yin Gao Mingwei Zhu Lingzhu Yu and Mingfa Li |
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Institution: | (1) MoE Key Laboratory of Developmental Genetics and Neuropsychiatric Diseases, Bio-X Center, School of Life Science and Biotechnology, Shanghai Jiao Tong University, 200240 Shanghai, PR, China |
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Abstract: | Background Proper patterning of the follicle cell epithelium over the egg chamber is essential for the Drosophila egg development. Differentiation of the epithelium into several distinct cell types along the anterior-posterior axis requires
coordinated activities of multiple signaling pathways. Previously, we reported that lethal(2)giant larvae (lgl), a Drosophila tumor suppressor gene, is required in the follicle cells for the posterior follicle cell (PFC) fate induction at mid-oogenesis.
Here we explore the role of another two tumor suppressor genes, scribble (scrib) and discs large (dlg), in the epithelial patterning. |
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