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Alterations in peripheral blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor |
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| Authors: | M Margarida Souto-Carneiro Vijayabhanu Mahadevan Kazuki Takada Ruth Fritsch-Stork Toshihiro Nanki Margaret Brown Thomas A Fleisher Mildred Wilson Raphaela Goldbach-Mansky Peter E Lipsky |
| Institution: | 1. Centro de Neurociências e Biologia Celular, Department of Zoology, University of Coimbra, 3004-517, Coimbra, Portugal 2. National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, 9000 Rockville Pike, 20892, Bethesda, MD, USA 3. Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1-5-45, Yushima, 113-8519, Bunkyo-ku, Tokyo, Japan 4. Department of Rheumatology, UMC Utrecht, Heidelberglaan 100, 3584, Utrecht, CX, The Netherlands 5. Department of Laboratory Medicine, Warren Magnuson Center, NIH, 9000 Rockville Pike, 20892, Bethesda, MD, USA |
| Abstract: | IntroductionDisturbances in peripheral blood memory B cell subpopulations have been observed in various autoimmune diseases, but have not been fully delineated in rheumatoid arthritis (RA). Additionally, the possible role of tumour necrosis factor (TNF) in regulating changes in specific peripheral blood memory B cell subsets in RA is still unclear. |
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