Correlation of oligomycin-sensitive ATPase activity in trypanosomes with their content of an antigen to primary biliary cirrhosis期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Correlation of oligomycin-sensitive ATPase activity in trypanosomes with their content of an antigen to primary biliary cirrhosis

Authors:	P Uzoegwu H Baum J Williamson

Affiliation:	1. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark;2. Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby 2800, Denmark;3. Cell Death and Metabolism group, Center for Autophagy, Recycling and Disease, Danish Cancer Institute, Copenhagen, Denmark;1. Instituto de Histología y Embriología de Mendoza (IHEM), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo (UNCuyo), Mendoza, Argentina;2. Facultad De Química, Bioquímica y Farmacia, Universidad Nacional De San Luis, San Luis, Argentina;3. Servicio de Neurología infantil, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina;4. Division of Metabolism, Bambino Gesù Children''s Hospital, Rome, Italy;5. PURA Foundation Australia, Plenty Victoria, Australia;6. Facultad de Ingeniería, Universidad Nacional de Cuyo (UNCuyo), Mendoza, Argentina;7. Instituto de Neurología Infantojuvenil (Neuroinfan), Mendoza, Argentina

Abstract:	The amounts of an antigen to primary biliary cirrhosis (PBC) which occur in subcellular fractions of Trypanosoma rhodesiense and T. lewisi correlate positively with the oligomycin-sensitive (OS) ATPase activity of these fractions. This result is consistent with the mitochondrial ATPase association of the antigen in mammalian and other cells. Higher levels of OS-ATPase and of PBC antigen in T. lewisi accord with a more extensive mitochondrial development in this species.

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