| Abstract: | Abstract— The effects of selective inactivation of propionylcholinesterase (PrChE) by tetramonoisopropylpyrophosphortetramide (iso-OMPA) on the steady state and regenerating levels of acetylcholinesterase (AChE) were investigated on the superior cervical ganglion (SCG) of the rat. Over the dosage range of 1.5-40.0 μmol iso-OMPA/kg intraperitoneally, which produced nearly total inactivation of ganglionic PrChE and 0-35% inactivation of AChE, there was no subsequent increase in AChE activity above the control level. Single or repeated injections of iso-OMPA at total doses of 5.0-40.0 μmol/kg intraperitoneally caused no reduction in the rate of regeneration of ganglionic AChE during the 24 h following its inactivation by sarin, 2.0 μmol/kg intravenously. Both sets of findings differ from those obtained previously in a similar study of ganglionic AChE and butyrylcholinesterase (BuChE) in the cat. Possible reasons for this distinct species difference are discussed. |
