Antinociceptive and other opioid effects of a new series of dermorphin analogues after subcutaneous administration in the rat |
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| Authors: | M A Cervini A C Rossi G Perseo R de Castiglione |
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| Affiliation: | 1. Ricerca and Sviluppo Biologico Farmitalia Carlo Erba SpA, Milano, Italy;2. Ricerca and Sviluppo Chimico Farmitalia Carlo Erba SpA, Milano, Italy |
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| Abstract: | A series of hepta-, hexa-, penta- and tetrapeptide analogues of dermorphin have been evaluated in the rat for antinociceptive activity after subcutaneous (SC) administration at the screening dose of 4 mg/kg. Effective doses (ED50) were calculated for the most active compounds. Presence of spontaneous movements, defecation, micturition and corneal reflex were also recorded. Syntheses and analytical data of new derivatives are briefly reported. |
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| Keywords: | Akinesia Analgesia Corneal reflex Defecation Dermorphin analogues Micturition Opioid peptides Rat Subcutaneous administration Synthetic peptides |
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