Searching tRNA sequences for relatedness to aminoacyl-tRNA synthetase families |
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Authors: | Hugh B Nicholas Jr William H McClain |
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Institution: | (1) Pittsburgh Supercomputing Center, 4400 Fifth Avenue, 15213-2683 Pittsburgh, PA, USA;(2) Department of Bacteriology, University of Wisconsin, 53706-1567 Madison, WI, USA |
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Abstract: | tRNA sequences were analyzed for sequence features correlated with known classes of aminoacyl-tRNA synthetase enzymes. The tRNAs were searched for distinguishing nucleotides anywhere in their sequences. The analyses did not find nucleotides predictive of synthetase class membership. We conclude that such nucleotides never existed in tRNA sequences or that they existed and were lost from many of the tRNA sequences during evolution.Based on a presentation made at a workshop— Aminoacyl-tRNA Synthetases and the Evolution of the Genetic Code —held at Berkeley, CA, July 17–20, 1994
Correspondence to: H.B. Nicholas, Jr. |
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Keywords: | Aminoacyl-tRNA synthetase Computer analysis Evolution Genetic code tRNA |
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