Role of macrophage inflammatory protein-1alpha in T-cell-mediated immunity to viral infection |
| |
| Authors: | Madsen Andreas N Nansen Anneline Christensen Jan P Thomsen Allan R |
| |
| Affiliation: | Institute of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark. |
| |
| Abstract: | The immune response to lymphocytic choriomeningitis virus in mice lacking macrophage inflammatory protein-1alpha (MIP-1alpha) was evaluated. Generation of virus-specific effector T cells is unimpaired in MIP-1alpha-deficient mice. Furthermore, MIP-1alpha is not required for T-cell-mediated virus control or virus-induced T-cell-dependent inflammation. Thus, MIP-1alpha is not mandatory for T-cell-mediated antiviral immunity. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
