Intracellular depletion of insulin by oleate is due to an inhibited synthesis and not to an increased secretion |
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| Authors: | Bollheimer L C Kestler T M Michel J Buettner R Schölmerich J Palitzsch K D |
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| Institution: | Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany. cornelius.bollheimer@klinik.uni-regensburg.de |
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| Abstract: | In the polyclonal rat pancreatic beta-cell line INS-1, immunoreactive insulin (IRI, insulin and its precursors) and C-peptide (surrogate marker for mature insulin) were quantified after a 1-h incubation at 16.7 mM glucose with or without oleate. Oleate caused a 20% decrease (P
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