Effect of different anesthetics on immunoreactive atrial natriuretic factor concentrations in rat plasma |
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| Authors: | K Horky J Gutkowska R Garcia G Thibault J Genest M Cantin |
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| Institution: | 1. Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464–8601, Japan;2. Department of Neural Regulation, Nagoya University Graduate School of Medicine, Nagoya 466–8550, Japan;3. JSPS Postdoctoral Fellowships for Research in Japan;4. Chinese Institute for Brain Research, Beijing (CIBR), Beijing 102206, China;5. National Institute for Physiological Sciences, National Institutes of Natural Sciences, Aichi 444–8585, Japan;6. Division of Brain Sciences Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160–8582, Japan;1. Department of Environmental and Preventive Medicine, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, 663-8501, Japan;2. Department of Cardiovascular Surgery, Yamagata Saisei Hospital, Yamagata, 990-8545, Japan;3. Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Urayasu, Japan;4. Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan |
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| Abstract: | The effect of different conditions of blood withdrawal and use of different anesthetics on immunoreactive atrial natriuretic factor (IR-ANF) concentrations in plasma was studied in rats. The concentration of IR-ANF in plasma from jugular vein of non-anesthetized conscious rats, cannulated either 24 hr before blood withdrawal was 93.9 +/- 17.1 pg/ml (n = 30); and 48 hr: 81.9 +/- 11.5 pg/ml (n = 29). Immobilization stress (4 hr) increased IR-ANF concentration: 248.0 +/- 80.2 pg/ml (n = 5). Anesthesia by morphine, diethyl-ether, chloral hydrate and ketamine chlorhydrate increased IR-ANF concentrations to 2,443.0 +/- 281.2 pg/ml (n = 24), 806.1 +/- 74.6 pg/ml (n = 64), 224.0 +/- 81.4 pg/ml (n = 20), and 195.0 +/- 20.3 pg/ml (n = 51), respectively. IR-ANF in plasma of sodium-pentobarbital and urethane anesthetized rats was 59.2 +/- 6.7 pg/ml (n = 10) and 42.6 +/- 8.1 pg/ml (n = 8), respectively. These changes in IR-ANF evoked by different types of anesthetics and different conditions of blood withdrawal have to be taken into consideration during studies on the physiopathological role of atrial natriuretic factor. |
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