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DAPI derivative: a fluorescent DNA dye that can be covalently attached to biomolecules |
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| Authors: | Li Min Wu Robert S Tsai Jane S C |
| Affiliation: | Roche Diagnostics Corporation, 9115 Hague Road, Indianapolis, IN 46250, USA |
| Abstract: | The preparation of a DAPI (4′,6-diamidino-2-phenylindole) derivative is described. The resulting derivative retains the fluorogenic property upon binding to double-stranded DNA. Its ability for bioconjugation through amide linkage is demonstrated. |
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