ADAM23 promotes neuronal differentiation of human neural progenitor cells |
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| Authors: | Annett Markus-Koch Oliver Schmitt Susanne Seemann Jan Lukas Dirk Koczan Mathias Ernst Georg Fuellen Andreas Wree Arndt Rolfs Jiankai Luo |
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| Institution: | 1.Albrecht-Kossel-Institute for Neuroregeneration,Rostock University Medical Center,Rostock,Germany;2.Institute of Anatomy,Rostock University Medical Center,Rostock,Germany;3.Institute for Immunology,Rostock University Medical Center,Rostock,Germany;4.Institute for Biostatistics and Informatics in Medicine and Ageing Research,Rostock University Medical Center,Rostock,Germany |
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| Abstract: | BackgroundADAM23 is widely expressed in the embryonic central nervous system and plays an important role in tissue formation.ResultsIn this study, we showed that ADAM23 contributes to cell survival and is involved in neuronal differentiation during the differentiation of human neural progenitor cells (hNPCs). Upregulation of ADAM23 in hNPCs was found to increase the number of neurons and the length of neurite, while its downregulation decreases them and triggers cell apoptosis. RNA microarray analysis revealed mechanistic insights into genes and pathways that may become involved in multiple cellular processes upon up- or downregulation of ADAM23.ConclusionsOur results suggest that ADAM23 regulates neuronal differentiation by triggering specific signaling pathways during hNPC differentiation. |
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