GTPases and the origin of the ribosome |
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Authors: | Hyman Hartman Temple F Smith |
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Institution: | (1) Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;(2) BioMolecular Engineering Research Center, Boston University, 36 Cummington Street, Boston, MA 02215, USA |
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Abstract: | Background This paper is an attempt to trace the evolution of the ribosome through the evolution of the universal P-loop GTPases that
are involved with the ribosome in translation and with the attachment of the ribosome to the membrane. The GTPases involved
in translation in Bacteria/Archaea are the elongation factors EFTu/EF1, the initiation factors IF2/aeIF5b + aeIF2, and the
elongation factors EFG/EF2. All of these GTPases also contain the OB fold also found in the non GTPase IF1 involved in initiation.
The GTPase involved in the signal recognition particle in most Bacteria and Archaea is SRP54. |
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Keywords: | |
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