Protective effect of zinc on liver injury induced byd-galactosamine in rats |
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Authors: | Heng-Long Hu Ren-Dun Chen Lian-Hu Ma |
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Institution: | (1) Department of Nutrition, Institute of Infectious Diseases, 26 Fengtai Road, 100039 Beijing, P. R. China |
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Abstract: | The protective effects of zinc on liver injury induced byd-galactosamine (GalN) were investigated in rats in vivo and in vitro. Zinc supplementation (50 mg/kg/d) for 5 d of rats treated
with GalN (1.5 g/kg, ip) could reduce their mortality rate, restore liver pathomorphological changes, maintain zinc content,
inhibit the lipid peroxidation, hasten the protein synthesis, and improve liver function. In vitro, zinc supplement could
abate the death of GalN-intoxicated hepatocytes, decrease malonaldehyde (MDA) content, and maintain reduced glutathione (GSH).
It is concluded that zinc has protective effects on GalN-induced liver damage. Its effects may be owing to inhibition of lipid
peroxidation and hastening of protein syntheses. |
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Keywords: | Zinc liver injury free radical lipid peroxidation galactosamine glutathione protein synthesis |
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