Murine mesenchymal cells that express elevated levels of the CDK inhibitor p16(Ink4a) in vivo are not necessarily senescent |
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Authors: | David Frescas Brandon M. Hall Evguenia Strom Lauren P. Virtuoso Mahima Gupta Anatoli S. Gleiberman |
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Affiliation: | Everon Biosciences, Inc., Buffalo, NY, USA |
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Abstract: | Age-related health decline has been attributed to the accumulation of senescent cells recognized in vivo by p16(Ink4a) expression. The pharmacological elimination of p16(Ink4a)-positive cells from the tissues of mice was shown to extend a healthy lifespan. Here, we describe a population of mesenchymal cells isolated from mice that are highly p16(INK4a)-positive are proficient in proliferation but lack other properties of cellular senescence. These data, along with earlier reports on p16(Ink4a)-positive macrophages, indicate that p16(Ink4a)-positive and senescent cell populations only partially intersect, therefore, extending the list of potential cellular targets for anti- aging therapies. |
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Keywords: | p16(Ink4a) senescence biomarkers senescence-associated β-galactosidase (SA-βGal) healthspan |
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