Long noncoding RNA lnc-sox5 modulates CRC tumorigenesis by unbalancing tumor microenvironment |
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Authors: | Kaiming Wu Zhenxian Zhao Kuanzhi Liu Jian Zhang Guanghua Li |
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Affiliation: | 1. Gastrointestinal Surgery Center, 1st Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China;2. Department of Pancreato-Biliary Surgery, 1st Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China;3. Department of Anaesthesiology, 1st Affiliated Hospital of Sun Yat-Sen Univesity, Guangzhou, Guangdong, P.R. China |
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Abstract: | Long non-coding RNAs (LncRNAs) have been recently regarded as systemic regulators in multiple biologic processes including tumorigenesis. In this study, we observed the expression of lncRNA lnc-sox5 was significantly increased in colorectal cancer (CRC). Despite the CRC cell growth, cell cycle and cell apoptosis was not affected by lnc-sox5 knock-down, lnc-sox5 knock-down suppressed CRC cell migration and invasion. In addition, xenograft animal model suggested that lnc-sox5 knock-down significantly suppressed the CRC tumorigenesis. Our results also showed that the expression of indoleamine 2,3-dioxygenase 1 (IDO1) was significantly reduced by lnc-sox5 knock-down and therefore modulated the infiltration and cytotoxicity of CD3+CD8+T cells. Taken together, these results suggested that lnc-sox5 unbalances tumor microenvironment to regulate colorectal cancer progression. |
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Keywords: | lnc-sox5 colorectal cancer (CRC) Indoleamine 2,3-dioxygenase 1 (IDO1) long non-coding RNA Tregs tumor microenvironment |
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