Arsenic trioxide inhibits cell growth and motility via up-regulation of let-7a in breast cancer cells |
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Authors: | Ying Shi Tong Cao Hua Huang Chaoqun Lian Ying Yang |
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Institution: | 1. Department of Biochemistry and Molecular Biology, Bengbu Medical College, Bengbu, Anhui, China;2. Research Center of Clinical Laboratory Science, Bengbu Medical College, Bengbu, Anhui, China |
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Abstract: | Arsenic trioxide (ATO) has been reported to exert its anti-cancer activities in human cancers. However, the molecular mechanism of ATO-triggered anti-tumor activity has not been fully elucidated. Recently, multiple studies demonstrated that ATO could regulate miRNAs in human cancers. Therefore, in this study, we investigated whether ATO regulated let-7a in breast cancer cells. We found that ATO upregulated let-7a level in breast cancer cells. We also found that up-regulation of let-7a inhibited cell growth and induced apoptosis and retarded cell migration and invasion. We also observed that up-regulation of let-7a enhanced cell growth inhibition and invasion suppression induced by ATO treatment. Our findings suggest that ATO suppressed cell growth, stimulated apoptosis, and retarded cell invasion partly via upregulation of let-7a in breast cancer cells. Our study provides a new anti-tumor mechanism of ATO treatment in breast cancer. |
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Keywords: | apoptosis Arsenic trioxide breast cancer cell growth Let-7a |
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