The genetics and expression of an esterase locus inAnopheles gambiae |
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Authors: | Kenneth D Vernick Frank H Collins Douglas C Seeley Robert W Gwadz Louis H Miller |
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Institution: | (1) Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 20892 Bethesda, Maryland;(2) Present address: Malaria Branch C-22, Division of Parasitic Diseases, Centers for Disease Control, 30333 Atlanta, Georgia |
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Abstract: | The main polymorphic system of esterase isoenzymes in adults of the G3 laboratory strain ofAnopheles gambiae consists of two to five major bands of activity per individual. The bands are designated 5S, 5F, 13, 14, and 15. In genetic
crosses, the genes which coded for the bands assorted as three codominant alleles, Est A, Est B, and Est C, at a single autosomal
locus. Homozygotes for the Est C allele were significantly underrepresented among backcross progeny. The developmental pattern
of esterase expression was examined. Esterase gene expression in embryos was first detectable between 2 and 12 hr after oviposition.
The initiation or termination of expression of some of the bands corresponded to boundaries between developmental stages.
Most of the esterase fractions were not specifically localized within the tissues tested, with the exception of a series of
bands which were restricted largely to adult male testes. |
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Keywords: | Anopheles gambiae malaria vector esterase |
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