Abstract: | Experimental evidencesuggesting a type of glucose uptake regulation prevailing inresting and differentiated cells was surveyed. This type of regulationis characterized by transport-limited glucose metabolism and depends onsegregation of glucose transporters on microvilli of differentiated orresting cells. Earlier studies on glucose transport regulation and arecently presented general concept of influx regulation for ions andmetabolic substrates via microvillar structures provide the basicframework for this theory. According to this concept, glucose uptakevia transporters on microvilli is regulated by changes in thestructural organization of the microfilament bundle, which is acting asa diffusion barrier between the microvillar tip compartment and thecytoplasm. Both microvilli formation and the switch of glucosemetabolism from "metabolic regulation" to "transportlimitation" occur during differentiation. The formation ofmicrovillar cell surfaces creates the essential preconditions toestablish the characteristic functions of specialized tissue cellsincluding the coordination between glycolysis and oxidativephosphorylation, regulation of cellular functions by external signals,and Ca2+ signaling. The proposed concept integrates variousaspects of glucose uptake regulation into a ubiquitous cellularmechanism involved in regulation of transmembrane ion and substrate fluxes. |