Increased expression of BAG-1 in rat brain cortex after traumatic brain injury |
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Authors: | Ting Xu Xueqian Wang Maohong Cao Xinmin Wu Yaohua Yan Hongran Fu Wei Zhao Peipei Gong Kaifu Ke Xingxing Gu |
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Institution: | The Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, Peoples Republic of China. |
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Abstract: | BAG-1 protein was initially identified as a Bcl-2-binding protein. It was reported to enhance Bcl-2 protection from cell death, suggesting that BAG-1 represents a new type of anti-cell death gene. Moreover, recent study has shown that BAG-1 can enhance the proliferation of neuronal precursor cells, attenuate the growth inhibition induced by siah1. However, its function and expression in the central nervous system lesion are not been understood very well. In this study, we performed a traumatic brain injury (TBI) model in adult rats and investigated the dynamic changes of BAG-1 expression in the brain cortex. Double immunofluorescence staining revealed that BAG-1 was co-expressed with NEURON and glial fibrillary acidic protein (GFAP). In addition, we detected that proliferating cell nuclear antigen had the co-localization with GFAP, and BAG-1. All our findings suggested that BAG-1 might involve in the pathophysiology of brain after TBI. |
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