Regions of mouse mammary tumor virus superantigen involved in interaction with the major histocompatibility complex class II I-A molecule |
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Authors: | Wirth Susanne Vessaz Annelyse Krummenacher Claude Baribaud Frédéric Acha-Orbea Hans Diggelmann Heidi |
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Affiliation: | Institute of Microbiology, University of Lausanne, CH-1011 Lausanne, Switzerland. Susanne.Wirth-dulex@chuv.hospvd.ch |
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Abstract: | To study the major histocompatibility complex class II I-E dependence of mouse mammary tumor virus (MMTV) superantigens, we constructed hybrids between the I-E-dependent MMTV(GR) and the I-E-independent mtv-7 superantigens and tested them in vivo. Our results suggest that, although the C-terminal third mediates I-A interaction, additional binding sites are located elsewhere in the superantigen. |
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