Nitroreductase activity of NADH dehydrogenase of the respiratory redox chain. |
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| Authors: | G E Smyth and B A Orsi |
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| Institution: | Department of Biochemistry, Trinity College, Dublin, Ireland. |
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| Abstract: | 1. An NADH-dependent nitroreductase from the inner membrane of ox liver mitochondria copurified with Complex I of the respiratory redox chain (NADH:ubiquinone oxidoreductase, EC 1.6.5.3). 2. The corresponding nitroreductase from ox heart mitochondria co-purified with the NADH-cytochrome c reductase of Mahler, Sarkar & Vernon (1952) J. Biol. Chem. 199, 585-597] NADH: (acceptor) oxidoreductase, EC 1.6.99.3], a component of Complex I that contains the FMN. 3. The mitochondrial nitroreductase activity is attributed to the flavoprotein component of Complex I. |
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