Molecular chaperones in cellular protein folding |
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Authors: | J rg Martin,F.-Ulrich Hartl |
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Affiliation: | Jörg Martin,F.-Ulrich Hartl |
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Abstract: | The discovery of “molecular chaperones” has dramatically changed our concept of cellular protein folding. Rather than folding spontaneously, most newly synthesized polypeptide chains seem to acquire their native conformation in a reaction mediated by these versatile helper proteins. Understanding the structure and function of molecular chaperones is likely to yield useful applications for medicine and biotechnology in the future. |
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