Sex determination in Drosophila melanogaster: X-linked genes involved in the initial step of Sex-lethal activation |
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Authors: | Lucas
nchez Begoa Granadino Miguel Torres |
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Institution: | Lucas Śnchez,Begoña Granadino,Miguel Torres |
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Abstract: | Sex determination is the commitment of an embryo to either the female or the male developmental pathway. The ratio of X chromosomes to sets of autosomes is the primary genetic signal that determines sex in Drosophila, by triggering the functional state of the gene Sex-lethal: in females (2X;2A) Sxl will be ON, whereas in males (X;2A) Sxl will be OFF. Genetic and molecuar studies have defined a set of genes involved in the formation of the X:A signal, as well as other genes, with either maternal or zygotic effects, which are also involved in regulating the initial step of Sex-lethal activation. We review these data and present new data on two more regions of the X chromosome that define other genes needed for Sxl activation. In addition, we report on the interaction between some of the genes regulating Sxl activation. © 1994 Wiley-Liss, Inc. |
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Keywords: | Drosophila sex determination X:A signal Sex-lethal activation |
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