Therapeutic potential of yeast killer toxin-like antibodies and mimotopes |
| |
Authors: | Magliani Walter Conti Stefania Salati Antonella Vaccari Simona Ravanetti Lara Maffei Domenico L Polonelli Luciano |
| |
Institution: | Sezione di Microbiologia, Dipartimento di Patologia e Medicina di Laboratorio, Università degli Studi di Parma, Viale Antonio Gramsci 14, 43100 Parma, Italy. magliwal@unipr.it |
| |
Abstract: | This review focuses on the potential of yeast killer toxin (KT)-like antibodies (KTAbs), that mimic a wide-spectrum KT through interaction with specific cell wall receptors (KTR) and their molecular derivatives (killer mimotopes), as putative new tools for transdisease anti-infective therapy. KTAbs are produced during the course of experimental and natural infections caused by KTR-bearing micro-organisms. They have been produced by idiotypic vaccination with a KT-neutralizing mAb, also in their monoclonal and recombinant formats. KTAbs and KTAbs-derived mimotopes may exert a strong therapeutic activity against mucosal and systemic infections caused by eukaryotic and prokaryotic pathogenic agents, thus representing new potential wide-spectrum antibiotics. |
| |
Keywords: | Yeast killer toxin Killer antibodies Killer mimotopes Antimicrobial therapy Anti-idiotypic antibiotics Anti-idiotypic therapy |
本文献已被 ScienceDirect PubMed 等数据库收录! |