Study of DNA sequence supraorganization by intramolecular renaturation

The method of DNA partial denaturation and intramolecular renaturation (in the absence of biomolecular reassociation) is developed analytically and presented as a means by which the supraorganization of the DNA sequences within large complex genomes may be studied. This analysis provides for the comparison of the actual borganization of DNA sequences with a random arrangement of the same sequences. The sequence organization of the E. coli genome does not appear to be very different from DNA sequences arranged along the genome without preference to sequence stabilities, whereas an orderly physical arrangement of DNA sequences is implicated for the human genoma.