O-Acetylation in the O-specific polysaccharide isolated from Shigella flexneri serotype 2a |
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| Authors: | Kubler-Kielb Joanna Vinogradov Evgeny Chu Chiayung Schneerson Rachel |
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| Institution: | National Institute of Child Health and Human Development, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. kielbj@mail.nih.gov |
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| Abstract: | Shigella flexneri causes diarrheal diseases especially in infants and children in developing countries. Modifications of the lipopolysaccharide (LPS) molecule, like bacteriophage-mediated glucosylation and acetylation of the O-specific chain (O-SP), are important for the LPS antigenicity and consequently for the immunogenicity of the polysaccharide-based vaccines against shigellosis. Here, we report the degree of O-acetylation and the localisation of O-acetyl groups and side-chain glucose substitution in the O-SP (scheme) in different preparations of S. flexneri type 2a LPS. structure: see text] |
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